Out of a sense of great respect, Muslims generally refrain from depicting the Prophet Muhammed and actually all the previous prophets, including Abraham, Moses, or Jesus, who are all highly revered in Islam.
This is a position similar to Rabbinic Judaism and a number of other anti-iconic Christian denominations. But the issue with both the Danish cartoons and the film was that they did not merely portray the Prophet Muhammed - they did so in an offensive and provocative manner.
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